Gene of the month: TMPRSS2 (transmembrane serine protease 2)
نویسندگان
چکیده
منابع مشابه
Efficient multiplication of human metapneumovirus in Vero cells expressing the transmembrane serine protease TMPRSS2.
Human metapneumovirus (HMPV) is a major causative agent of severe bronchiolitis and pneumonia. Its fusion (F) protein must be cleaved by host proteases to cause membrane fusion, a critical step for virus infection. By generating Vero cells constitutively expressing the transmembrane serine protease TMPRSS2 and green fluorescent protein-expressing recombinant HMPV, we show that TMPRSS2, which is...
متن کاملThe membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.
TMPRSS2 is a type II transmembrane-bound serine protease that has gained interest owing to its highly localized expression in the prostate and its overexpression in neoplastic prostate epithelium. Once activated, the serine protease domain of TMPRSS2 is released from the cell surface into the extracellular space. PAR (protease-activated receptor)-2 belongs to a family of G-protein-coupled recep...
متن کاملEnteropeptidase, a type II transmembrane serine protease.
Enteropeptidase, a type II transmembrane serine protease, is localized to the brush border of the duodenal and jejunal mucosa. It is synthesized as a zymogen (proenteropeptidase) that requires activation by another protease, either trypsin or possibly duodenase. Active enteropeptidase then converts the pancreatic precursor, trypsinogen, to trypsin by cleavage of the specific trypsinogen activat...
متن کاملProstate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.
Genes regulated by androgenic hormones are of critical importance for the normal physiological function of the human prostate gland, and they contribute to the development and progression of prostate carcinoma. We used cDNA microarrays containing 1500 cDNAs to profile transcripts regulated by androgens in prostate cancer cells and identified the serine protease TMPRSS2 as a gene exhibiting incr...
متن کاملA novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer.
We report the characterization of a novel serine protease of the chymotrypsin family, recently isolated by cDNA-representational difference analysis, as a gene overexpressed in pancreatic cancer. The 2.3-kb mRNA of the gene, named TMPRSS3, is strongly expressed in a subset of pancreatic cancer and various other cancer tissues, and its expression correlates with the metastatic potential of the c...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 2020
ISSN: 0021-9746,1472-4146
DOI: 10.1136/jclinpath-2020-206987